Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565611 | 0.93 | NTRK1 (0.48) | NTRK1NTRK3NTRK2NUAK1ULK1 | |
| SCHEMBL2568935 | 0.85 | NTRK1 (0.60) | NTRK1NUAK1 | |
| SCHEMBL28798102 | 0.85 | IGF1R (0.48) | NTRK1NTRK3NTRK2ULK1 | |
| SCHEMBL2564291 | 0.82 | NTRK1 (0.65) | NTRK1NUAK1 | |
| SCHEMBL27872744 | 0.81 | IGF1R (0.52) | NTRK1NTRK3NTRK2ULK1 | |
| SCHEMBL2565272 | 0.79 | NTRK1 (0.64) | NTRK1 | |
| SCHEMBL27856027 | 0.79 | NTRK1 (0.64) | NTRK1 | |
| SCHEMBL3127022 | 0.76 | NTRK1 (0.68) | NTRK1 | |
| SCHEMBL2572107 | 0.76 | NTRK1 (0.66) | NTRK1 | |
| SCHEMBL2572103 | 0.76 | NTRK1 (0.66) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383268-B1 | PYRAZOLYLAMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2015-09-02 | — | — | EP | disclosed |
| EP-2383268-A1 | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | AstraZeneca AB (SE) | 2011-11-02 | — | — | EP | disclosed |
| EP-1853602-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-07-14 | — | — | EP | disclosed |
| US-20080108669-A1 | Use 541 | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108669-A1 | Use 541 | TRPV1, P2RX3, P2RX5 | NTRK1 3837/4885NTRK3 4136/4885NTRK2 3067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.