Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30310735 | 0.78 | HRH4 (0.76) | HRH4IDO1FLT3KMT2AMEN1 | |
| SCHEMBL24020743 | 0.78 | HRH4 (0.76) | HRH4IDO1FLT3KMT2AMEN1 | |
| SCHEMBL913914 | 0.76 | FLT3 (0.68) | HRH4IDO1FLT3KMT2AMEN1 | |
| SCHEMBL29414307 | 0.76 | FLT3 (0.68) | HRH4IDO1FLT3KMT2AMEN1 | |
| SCHEMBL7979026 | 0.76 | FLT3 (0.68) | HRH4IDO1FLT3KMT2AMEN1 | |
| SCHEMBL12428148 | 0.75 | ALDH1A1 (0.58) | HRH4FLT3KMT2AMEN1POLB | |
| SCHEMBL6396188 | 0.75 | FLT3 (0.54) | HRH4IDO1FLT3DRD2DRD3 | |
| SCHEMBL217459 | 0.74 | FLT3 (0.66) | HRH4IDO1FLT3KMT2AMEN1 | |
| SCHEMBL24447653 | 0.74 | FLT3 (0.66) | HRH4IDO1FLT3KMT2AMEN1 | |
| SCHEMBL24113092 | 0.74 | FLT3 (0.66) | HRH4IDO1FLT3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167058-A1 | GPX4 COMPOUNDS AND COMPOSITIONS AND METHODS OF TREATMENT USING SAME | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167058-A1 | GPX4 COMPOUNDS AND COMPOSITIONS AND METHODS OF TREATMENT USING SAME | GPX4, GPX1, AIFM2 | HRH4 2426/4885IDO1 2654/4885FLT3 2232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.