Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | KHK | P50053 | 3/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13106381 | 0.83 | GAA (0.40) | GAAALDH1A1MAPK1L3MBTL1HTR2A | |
| SCHEMBL13106386 | 0.83 | GAA (0.40) | GAAALDH1A1MAPK1L3MBTL1HTR2A | |
| SCHEMBL19084512 | 0.77 | ADORA2A (0.42) | GAAALDH1A1MAPK1SYKGLA | |
| SCHEMBL25667934 | 0.74 | SYK (0.33) | GAAALDH1A1MAPK1L3MBTL1SYK | |
| SCHEMBL13106443 | 0.72 | GAA (0.36) | GAAALDH1A1MAPK1L3MBTL1MAPK8 | |
| SCHEMBL23870234 | 0.70 | PIM1 (0.34) | GAAALDH1A1MAPK1L3MBTL1GRM4 | |
| SCHEMBL13106356 | 0.70 | ESR1 (0.43) | ALDH1A1MAPK1L3MBTL1MAPK8MAPK9 | |
| SCHEMBL14077453 | 0.70 | L3MBTL1 (0.41) | GAAALDH1A1MAPK1L3MBTL1KHK | |
| SCHEMBL13106354 | 0.70 | ALDH1A1 (0.41) | GAAALDH1A1MAPK1L3MBTL1KHK | |
| SCHEMBL27153773 | 0.70 | DDB1 (0.45) | GAAALDH1A1MAPK1L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203018-A1 | COVALENT INHIBITORS OF KRAS | ARAXES PHARMA LLC (US) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203018-A1 | COVALENT INHIBITORS OF KRAS | KRAS, NRAS, HRAS | GAA 3195/4885ALDH1A1 1640/4885MAPK1 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.