Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.37 |
| ▸ | ACACA | Q13085 | 3/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25209962 | 0.88 | EGLN2 (0.39) | AKR1C3EGLN2CYP17A1ULK1FYN | |
| SCHEMBL25680124 | 0.84 | P2RX7 (0.38) | AKR1C3ACACBACACACYP17A1FYN | |
| SCHEMBL30438769 | 0.83 | ULK1 (0.40) | AKR1C3EGLN2CYP17A1ULK1FYN | |
| SCHEMBL25218243 | 0.83 | ULK1 (0.40) | AKR1C3EGLN2CYP17A1ULK1FYN | |
| SCHEMBL29253936 | 0.83 | EGLN2 (0.38) | AKR1C3EGLN2CYP17A1ULK1FYN | |
| SCHEMBL25680022 | 0.83 | P2RX7 (0.41) | AKR1C3ACACBACACACYP17A1FYN | |
| SCHEMBL29253937 | 0.80 | PDK2 (0.45) | CHEK1ABL1 | |
| Trifluoroacetic Acid SCHEMBL30439151 | 0.79 | EGLN2 (0.41) | AKR1C3EGLN2CYP17A1ULK1CHEK1 | |
| SCHEMBL30438905 | 0.78 | HDAC4 (0.57) | ACACBACACADYRK1A | |
| SCHEMBL25210972 | 0.74 | CHEK1 (0.50) | FYNCHEK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122167-A1 | Pyrazine Compounds Useful in the Treatment of Parasitic Protozoal Infection | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2025-04-17 | — | — | US | disclosed |
| EP-4436960-A1 | PYRAZINE COMPOUNDS USEFUL IN THE TREATMENT OF PARASITIC PROTOZOAL INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2024-10-02 | — | — | EP | disclosed |
| CN-118355005-A | Pyrazine compounds for the treatment of parasitic protozoal infections | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-07-16 | — | — | CN | disclosed |
| WO-2023094305-A1 | PYRAZINE COMPOUNDS USEFUL IN THE TREATMENT OF PARASITIC PROTOZOAL INFECTION | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-06-01 | — | — | WO | disclosed |
| WO-2023094305-A1 | PYRAZINE COMPOUNDS USEFUL IN THE TREATMENT OF PARASITIC PROTOZOAL INFECTION | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122167-A1 | Pyrazine Compounds Useful in the Treatment of Parasitic Protozoal Infection | CYP3A5, CYP3A43, CYP51A1 | LATS1 1398/4885AKR1C3 1239/4885ACACB 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.