Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 3/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25218243 | 1.00 | ULK1 (0.40) | ULK1IKBKBTGFBR1EGLN2PIK3CG | |
| Trifluoroacetic Acid SCHEMBL30439151 | 0.95 | EGLN2 (0.41) | ULK1IKBKBTGFBR1EGLN2AKR1C3 | |
| SCHEMBL25209962 | 0.87 | EGLN2 (0.39) | ULK1EGLN2AKR1C3CYP17A1FYN | |
| SCHEMBL29253936 | 0.86 | EGLN2 (0.38) | ULK1EGLN2AKR1C3CYP17A1FYN | |
| SCHEMBL25680207 | 0.83 | LATS1 (0.39) | ULK1EGLN2AKR1C3CYP17A1FYN | |
| SCHEMBL30438994 | 0.79 | DYRK1A (0.39) | AKR1C3CHEK1CLK1DYRK1A | |
| SCHEMBL25257863 | 0.79 | DYRK1A (0.39) | AKR1C3CHEK1CLK1DYRK1A | |
| Hydrochloric Acid SCHEMBL30439503 | 0.78 | DYRK1A (0.38) | AKR1C3CYP17A1CHEK1CLK1DYRK1A | |
| SCHEMBL25680124 | 0.78 | P2RX7 (0.38) | AKR1C3CYP17A1FYNDYRK1A | |
| SCHEMBL25213710 | 0.78 | DYRK1A (0.38) | AKR1C3CHEK1TLR7DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436960-A1 | PYRAZINE COMPOUNDS USEFUL IN THE TREATMENT OF PARASITIC PROTOZOAL INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2024-10-02 | — | — | EP | disclosed |
| WO-2023094305-A1 | PYRAZINE COMPOUNDS USEFUL IN THE TREATMENT OF PARASITIC PROTOZOAL INFECTION | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-06-01 | — | — | WO | disclosed |