Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25680262 | 1.00 | CES2 (0.48) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL9988312 | 0.81 | CES2 (0.52) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL18554929 | 0.79 | ALDH1A1 (0.55) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL18554931 | 0.79 | ALDH1A1 (0.55) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL25693266 | 0.79 | CES2 (0.42) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL18591429 | 0.79 | CES2 (0.42) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL18555131 | 0.79 | ALDH1A1 (0.55) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL9824671 | 0.79 | CES2 (0.50) | CES2CES1ALDH1A1POLBTSHR | |
| SCHEMBL18591431 | 0.78 | CES2 (0.41) | CES2CES1ALDH1A1POLBLMNA | |
| SCHEMBL18591423 | 0.78 | CES2 (0.41) | CES2CES1ALDH1A1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114198-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |