Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25680284 | 0.87 | LMNA (0.70) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL20511023 | 0.86 | MAPT (0.57) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| Hydrochloric Acid SCHEMBL20511056 | 0.86 | MAPT (0.56) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| Hydrochloric Acid SCHEMBL30186429 | 0.86 | MAPT (0.56) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL25680337 | 0.85 | AKR1C3 (0.61) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL25680426 | 0.84 | MAPT (0.55) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL25680349 | 0.84 | SMN1; SMN2 (0.61) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL20511016 | 0.83 | HPGD (0.53) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL25681397 | 0.83 | MAPT (0.53) | HPGDLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL30186402 | 0.82 | AKR1C3 (0.61) | HPGDLMNASMN1; SMN2MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142508-A1 | COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION | THE BROAD INSTITUTE, INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230142508-A1 | COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION | THE BROAD INSTITUTE, INC. (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142508-A1 | COMPOUNDS AND METHODS FOR REGULATING INSULIN SECRETION | IAPP, GPR119, PNLIP | HPGD 2210/4885LMNA 4022/4885SMN1; SMN2 4513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.