Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.63 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | FOXO3 | O43524 | 1/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.63 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.63 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.63 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.63 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.63 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25681948 | 1.00 | ALDH1A1 (0.63) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL25681916 | 1.00 | ALDH1A1 (0.63) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL173117 | 0.96 | ALDH1A1 (0.66) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL30496625 | 0.92 | ALDH1A1 (0.63) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL25238224 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL25279817 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL25288385 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL25240648 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL25282131 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL25288386 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TP53SMN1; SMN2MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250057963-A1 | DISCOVERY OF PIPERLONGUMINE AS A NOVEL E3 LIGASE LIGAND | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2025-02-20 | — | — | US | disclosed |
| WO-2023114455-A1 | DISCOVERY OF PIPERLONGUMINE AS A NOVEL E3 LIGASE LIGAND | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114455-A1 | DISCOVERY OF PIPERLONGUMINE AS A NOVEL E3 LIGASE LIGAND | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250057963-A1 | DISCOVERY OF PIPERLONGUMINE AS A NOVEL E3 LIGASE LIGAND | CDK10, CDK20, CDK9 | ALDH1A1 1803/4885TP53 265/4885SMN1; SMN2 4433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.