Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | FDPS | P14324 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 11/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27041606 | 0.86 | KDM4E (0.53) | KDM4ENAPRTFDPSTBXAS1LMNA | |
| SCHEMBL27041597 | 0.86 | KDM4E (0.53) | KDM4ENAPRTFDPSTBXAS1LMNA | |
| SCHEMBL15258874 | 0.82 | ALDH1A1 (0.47) | KDM4ENAPRTFDPSTBXAS1CYP1A2 | |
| SCHEMBL4412334 | 0.81 | HCAR2 (0.39) | KDM4ENAPRTTBXAS1CYP1A2CYP3A4 | |
| SCHEMBL6885074 | 0.81 | KDM4E (0.62) | KDM4ENAPRTFDPSTBXAS1LMNA | |
| SCHEMBL10744809 | 0.81 | FDPS (0.46) | KDM4ENAPRTFDPSTBXAS1LMNA | |
| SCHEMBL2561452 | 0.81 | CYP1A2 (0.57) | CYP1A2 | |
| SCHEMBL7384333 | 0.80 | CYP1A2 (0.62) | KDM4ENAPRTFDPSTBXAS1LMNA | |
| SCHEMBL11235663 | 0.79 | FDPS (0.43) | KDM4ENAPRTFDPSTBXAS1LMNA | |
| SCHEMBL31326469 | 0.78 | NAPRT (0.54) | KDM4ENAPRTFDPSTBXAS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382205-B1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI SA (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2382205-A2 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076524-A2 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | WO | disclosed |