Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25234927 | 0.83 | PTK2 (0.49) | PTK2PTK2B | |
| SCHEMBL24716006 | 0.83 | ULK1 (0.48) | ULK1PTK2MAPK3CDK1CDK4 | |
| SCHEMBL25056242 | 0.81 | IGF1R (0.48) | IGF1RLRRK2 | |
| SCHEMBL17102732 | 0.79 | PTK2 (0.45) | ULK1PTK2MAPK3CDC7ROCK2 | |
| SCHEMBL12813038 | 0.77 | CDC7 (0.52) | ULK1PTK2MAPK3CDC7ROCK2 | |
| SCHEMBL28295859 | 0.77 | ULK1 (0.47) | ULK1PTK2MAPK3CDK1CDK4 | |
| SCHEMBL25692191 | 0.76 | GSK3A (0.69) | PTK2MAPK3CDC7ROCK2MAP4K4 | |
| SCHEMBL24715923 | 0.76 | ULK1 (0.44) | ULK1PTK2MAPK3CDK1CDK4 | |
| SCHEMBL28969607 | 0.76 | ULK1 (0.52) | ULK1PTK2MAPK3CDK1CDK4 | |
| SCHEMBL19831480 | 0.75 | CDC7 (0.50) | ULK1PTK2MAPK3CDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023121251-A1 | EGFR AND HDAC DUAL INHIBITOR COMPOUNDS AND MEDICAL USE THEREOF | 한국원자력의학원 | 2023-06-29 | — | — | WO | disclosed |