Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 3/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24715923 | 0.88 | ULK1 (0.44) | ULK1PTK2MAPK3CDC7ROCK2 | |
| SCHEMBL29575332 | 0.85 | ULK1 (0.66) | ULK1PTK2MAPK3CDC7ROCK2 | |
| SCHEMBL17547451 | 0.85 | ULK1 (0.66) | ULK1PTK2MAPK3CDC7ROCK2 | |
| SCHEMBL25692091 | 0.83 | ULK1 (0.44) | ULK1PTK2MAPK3CDC7ROCK2 | |
| SCHEMBL30223473 | 0.82 | CCNA2 (0.44) | ULK1PTK2CDK9CDK2STK10 | |
| SCHEMBL24073506 | 0.82 | CCNA2 (0.44) | ULK1PTK2CDK9CDK2STK10 | |
| SCHEMBL28295859 | 0.81 | ULK1 (0.47) | ULK1PTK2MAPK3CDC7ROCK2 | |
| SCHEMBL4025891 | 0.80 | IGF1R (0.52) | PTK2IGF1RLRRK2 | |
| SCHEMBL30833716 | 0.80 | IGF1R (0.52) | PTK2IGF1RLRRK2 | |
| SCHEMBL25278838 | 0.79 | ULK1 (0.45) | ULK1PTK2MAPK3CDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022214008-A1 | HIGHLY ACTIVE HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-10-13 | — | — | WO | disclosed |