Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14248722 | 0.81 | TAAR1 (0.53) | LMNAKDM4EPOLBMCOLN3TAAR1 | |
| SCHEMBL4857267 | 0.78 | TAAR1 (0.44) | LMNAALDH1A1KDM4EUSP2MMP9 | |
| SCHEMBL14248769 | 0.75 | DAO (0.41) | ALDH1A1TAAR1PTGS2SOS1 | |
| SCHEMBL15229213 | 0.75 | KCNH2 (0.42) | LMNAALDH1A1KDM4EUSP2MMP9 | |
| SCHEMBL20187418 | 0.75 | NR3C1 (0.39) | SOS1ADRA1DADRA1AADRA1B | |
| SCHEMBL11046462 | 0.75 | ALDH1A1 (0.40) | LMNAALDH1A1KDM4EUSP2MMP9 | |
| SCHEMBL3130844 | 0.75 | KDM4E (0.40) | LMNAALDH1A1KDM4EUSP2MMP9 | |
| SCHEMBL5539055 | 0.74 | LMNA (0.37) | LMNAALDH1A1KDM4EUSP2MMP9 | |
| SCHEMBL20303484 | 0.73 | PSEN1 (0.39) | LMNAALDH1A1KDM4EUSP2MMP9 | |
| SCHEMBL5034014 | 0.71 | KDM4E (0.40) | LMNAALDH1A1KDM4EUSP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2381777-A1 | AZAINDOLE DERIVATIVES AS KINASE INHIBITORS | ARIAD Pharmaceuticals, Inc (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010068292-A1 | AZAINDOLE DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |