Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL160484 | 0.84 | DGAT1 (0.36) | NPC1DGAT1 | |
| SCHEMBL25219333 | 0.81 | DGAT1 (0.39) | NPC1DGAT1 | |
| SCHEMBL31381549 | 0.80 | DGAT1 (0.33) | NPC1DGAT1 | |
| SCHEMBL25408348 | 0.78 | DGAT1 (0.34) | NPC1DGAT1 | |
| SCHEMBL25697511 | 0.78 | NPC1 (0.34) | NPC1DGAT1 | |
| SCHEMBL29109010 | 0.77 | KDM4E (0.34) | NPC1DGAT1 | |
| SCHEMBL173652 | 0.76 | ALDH1A1 (0.38) | DGAT1 | |
| SCHEMBL25697513 | 0.76 | NPC1 (0.33) | NPC1DGAT1 | |
| SCHEMBL31022044 | 0.75 | DGAT1 (0.33) | NPC1DGAT1 | |
| SCHEMBL19981708 | 0.75 | DGAT1 (0.30) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | PIR, CYP3A43, CYP1A2 | NPC1 1354/4885DGAT1 4685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.