Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.30 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26546522 | 0.79 | GAA (0.35) | GAAPKMALOX15HSD17B10CES2 | |
| SCHEMBL10060476 | 0.77 | CES2 (0.41) | TSHRGAAPKMLMNACES2 | |
| SCHEMBL19059411 | 0.73 | YEATS4 (0.51) | TSHRGAALMNACES2CES1 | |
| SCHEMBL3195402 | 0.72 | CES2 (0.65) | GAACES2CES1HPGDALDH1A1 | |
| SCHEMBL12744773 | 0.70 | DAO (0.59) | HSD17B10HPGDALDH1A1L3MBTL1TAS1R3 | |
| SCHEMBL17050413 | 0.70 | GSK3B (0.52) | TSHRGAALMNACES2CES1 | |
| SCHEMBL10161072 | 0.70 | DAO (0.54) | GAAPKMHPGDALDH1A1HDAC3 | |
| SCHEMBL10161070 | 0.69 | NPSR1 (0.53) | TSHRLMNAHPGDALDH1A1L3MBTL1 | |
| SCHEMBL13423078 | 0.68 | F2 (0.57) | GAALMNAHPGDALDH1A1MAPK1 | |
| SCHEMBL12553236 | 0.68 | DAO (0.42) | TSHRGAALMNACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230149550-A1 | METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE | Design Therapeutics, Inc. | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230149550-A1 | METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE | DMPK, DTYMK, MYCBP | TSHR 2145/4885GAA 507/4885PKM 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.