Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.38 |
| ▸ | CYP3A5 | P20815 | 3/20 | 0.38 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.37 |
| ▸ | PI4KA | P42356 | 2/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1165291 | 0.81 | ALDH1A1 (0.42) | ALDH1A1BRD4CYP3A4CYP3A5PI4KA | |
| SCHEMBL323982 | 0.78 | ALDH1A1 (0.52) | ALDH1A1BRD4CYP3A4CYP3A5PBK | |
| SCHEMBL3974202 | 0.74 | ALDH1A1 (0.46) | ALDH1A1BRD4CYP3A4CYP3A5PI4KA | |
| SCHEMBL2001257 | 0.73 | ALDH1A1 (0.42) | ALDH1A1BRD4CYP3A4CYP3A5PBK | |
| SCHEMBL7108989 | 0.69 | PI4KA (0.50) | ALDH1A1BRD4CYP3A4CYP3A5PI4KA | |
| SCHEMBL2493987 | 0.69 | BRD4 (0.51) | ALDH1A1BRD4PI4KAPI4K2BPI4K2A | |
| SCHEMBL22830483 | 0.69 | ALDH1A1 (0.46) | ALDH1A1BRD4CYP3A4CYP3A5PI4KA | |
| SCHEMBL29367441 | 0.69 | PI4KA (0.50) | ALDH1A1BRD4CYP3A4CYP3A5PI4KA | |
| SCHEMBL1165562 | 0.69 | ALDH1A1 (0.46) | ALDH1A1BRD4CYP3A4CYP3A5PI4KA | |
| SCHEMBL19778900 | 0.69 | ALDH1A1 (0.46) | ALDH1A1BRD4CYP3A4CYP3A5PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786812-B1 | PYRIDINE METHYLENE AZOLIDINONES AND THEIR USE AS PHOSPHOINOSITIDE INHIBITORS | MERCK SERONO SA (CH) | 2011-11-09 | — | — | EP | disclosed |
| US-7842698-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO S.A. (CH) | 2010-11-30 | — | — | US | disclosed |
| US-20080269227-A1 | Pyridine Methylene Azolidinones and Use Thereof Phosphoinositide Inhibitors | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269227-A1 | Pyridine Methylene Azolidinones and Use Thereof Phosphoinositide Inhibitors | PIK3CD, PIK3CA, PIK3CB | ALDH1A1 1437/4885CCR1 4123/4885CCR5 1931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.