Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 4/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.41 |
| ▸ | PI4KA | P42356 | 2/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30788403 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP3A5BRD4PI4KA | |
| SCHEMBL29367441 | 0.74 | PI4KA (0.50) | ALDH1A1CYP3A4CYP3A5BRD4PI4KA | |
| SCHEMBL29804946 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP3A5BRD4DAO | |
| SCHEMBL3974202 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP3A5BRD4PI4KA | |
| SCHEMBL2493987 | 0.74 | BRD4 (0.51) | ALDH1A1BRD4PI4KAPI4K2BPI4K2A | |
| SCHEMBL7108989 | 0.74 | PI4KA (0.50) | ALDH1A1CYP3A4CYP3A5BRD4PI4KA | |
| SCHEMBL323982 | 0.74 | ALDH1A1 (0.52) | ALDH1A1CYP3A4CYP3A5BRD4PI4KA | |
| SCHEMBL19778900 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP3A5BRD4CDC7 | |
| SCHEMBL22830483 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP3A5BRD4PI4KA | |
| SCHEMBL2009562 | 0.74 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP3A5BRD4PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117050073-B | Polysubstituted phenyl bisimidazopyridine compound and synthetic method and application thereof | 中国药科大学 | 2025-06-10 | — | — | CN | disclosed |
| CN-117050073-A | Polysubstituted phenyl bisimidazopyridine compound and synthetic method and application thereof | 中国药科大学 | 2023-11-14 | — | — | CN | disclosed |
| CN-117050074-A | Pyridine bisimidazopyridine compound and preparation method and application thereof | 中国药科大学 | 2023-11-14 | — | — | CN | disclosed |
| CN-117050075-A | Biaryl ring BET inhibitor and synthetic method and application thereof | 中国药科大学 | 2023-11-14 | — | — | CN | disclosed |
| EP-3131897-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2022-06-15 | — | — | EP | disclosed |
| EP-3159335-B1 | NOVEL HETEROCYCLIC COMPOUND | DAE WOONG PHARMA (KR) | 2020-04-29 | — | — | EP | disclosed |
| EP-3131896-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2019-01-30 | — | — | EP | disclosed |
| US-10081634-B2 | Heterocyclic compound | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2018-09-25 | — | — | US | disclosed |
| US-9969724-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9808445-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-8058289-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO SA (CH) | 2011-11-15 | — | — | US | disclosed |
| EP-1786812-B1 | PYRIDINE METHYLENE AZOLIDINONES AND THEIR USE AS PHOSPHOINOSITIDE INHIBITORS | MERCK SERONO SA (CH) | 2011-11-09 | — | — | EP | disclosed |
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2011-02-10 | — | — | US | disclosed |
| US-7842698-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO S.A. (CH) | 2010-11-30 | — | — | US | disclosed |
| US-7576072-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-20080269227-A1 | Pyridine Methylene Azolidinones and Use Thereof Phosphoinositide Inhibitors | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2008-10-30 | — | — | US | disclosed |
| EP-1689406-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-17 | — | — | EP | disclosed |
| EP-1689406-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| US-20050153942-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. | 2005-07-14 | — | — | US | disclosed |
| WO-2005051906-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269227-A1 | Pyridine Methylene Azolidinones and Use Thereof Phosphoinositide Inhibitors | PIK3CD, PIK3CA, PIK3CB | ALDH1A1 1437/4885CYP3A4 1562/4885CYP3A5 1084/4885 |
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | PIK3CD, PIK3CA, PTEN | ALDH1A1 1232/4885CYP3A4 1632/4885CYP3A5 1066/4885 |
| US-20050153942-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | NRAS, BRAF, MAPK9 | ALDH1A1 2094/4885CYP3A4 1192/4885CYP3A5 768/4885 |
| US-10081634-B2 | Heterocyclic compound | AARS1, NSUN3, RNASE1 | ALDH1A1 1349/4885CYP3A4 2706/4885CYP3A5 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.