SCHEMBL25712964

SCHEMBL25712964

CCOC(=O)c1cc2c(nc(CN3CC=C(c4ccc(Cl)c(O)c4)CC3)n2COCC[Si](C)(C)C)s1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SUV39H2 Q9H5I1 5/20 0.34
PPARG P37231 5/20 0.34
PPARA Q07869 5/20 0.34
EGLN1 Q9GZT9 1/20 0.33
ALDH1A1 P00352 2/20 0.31
MAPT P10636 2/20 0.31
PKM P14618 1/20 0.31
QDPR P09417 1/20 0.31
GAA P10253 2/20 0.31
KDM4E B2RXH2 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
HSP90AA1 P07900 1/20 0.30
TRPV1 Q8NER1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25119888 0.83 CCNT1 (0.31)
SCHEMBL25119891 0.82 CCNT1 (0.30)
SCHEMBL24400514 0.79 GLP1R (0.39)
SCHEMBL25675290 0.78 GLP1R (0.41)
SCHEMBL25980165 0.77 GLP1R (0.36)
SCHEMBL25980108 0.77 GLP1R (0.36)
SCHEMBL25120294 0.76 PPARG (0.37) PPARGPPARA
SCHEMBL24401144 0.76 MAPT (0.36) ALDH1A1MAPTPKMGAAKDM4E
SCHEMBL25712965 0.75 GLP1R (0.40)
SCHEMBL24401142 0.75 ALDH1A1 (0.36) ALDH1A1MAPTPKMGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230203057-A1 FIVE-MEMBERED HETEROAROMATIC IMIDAZOLE COMPOUND AND USE THEREOF HANGZHOU SCIWIND BIOSCIENCES CO., LTD (CN) 2023-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230203057-A1 FIVE-MEMBERED HETEROAROMATIC IMIDAZOLE COMPOUND AND USE THEREOF GLP1R, GIPR, GPR119 SUV39H2 998/4885PPARG 305/4885PPARA 1424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.