Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.46 |
| ▸ | KDR | P35968 | 9/20 | 0.42 |
| ▸ | FLT3 | P36888 | 7/20 | 0.42 |
| ▸ | KIT | P10721 | 6/20 | 0.42 |
| ▸ | LCK | P06239 | 4/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.42 |
| ▸ | FLT1 | P17948 | 4/20 | 0.42 |
| ▸ | FLT4 | P35916 | 4/20 | 0.42 |
| ▸ | LYN | P07948 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | BLK | P51451 | 3/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25716455 | 0.87 | EGFR (0.39) | BTKKDRFLT3KITLCK | |
| SCHEMBL25715071 | 0.86 | BTK (0.49) | BTKKDRFLT3KITLCK | |
| SCHEMBL25718089 | 0.80 | BTK (0.41) | BTKFLT3EGFRFGFR1CYP3A4 | |
| SCHEMBL25715122 | 0.80 | BTK (0.49) | BTKKDRFLT3KITLCK | |
| SCHEMBL25716316 | 0.78 | EPHB4 (0.40) | BTKKDRFLT3KITLCK | |
| SCHEMBL25716405 | 0.77 | CYP3A4 (0.45) | BTKKDRFLT3KITLCK | |
| SCHEMBL25715151 | 0.76 | BTK (0.40) | BTKKDRFLT3KITLCK | |
| SCHEMBL22676063 | 0.75 | FGFR1 (0.56) | BTKFLT3SRCBLKEGFR | |
| SCHEMBL30586235 | 0.75 | FGFR1 (0.56) | BTKFLT3SRCBLKEGFR | |
| SCHEMBL25714929 | 0.74 | KIT (0.51) | BTKKDRFLT3KITLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104035-A1 | SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 英矽智能科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |