Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | BTK | Q06187 | 10/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25714928 | 0.79 | BTK (0.47) | FLT3BTKEGFRNPC1RAB9A | |
| SCHEMBL25714644 | 0.78 | BTK (0.55) | FLT3BTKEGFRSRCBLK | |
| SCHEMBL25714979 | 0.74 | BTK (0.46) | KITFLT3BTKEGFRKDR | |
| SCHEMBL25715071 | 0.73 | BTK (0.49) | KITFLT3BTKEGFRKDR | |
| SCHEMBL22009047 | 0.73 | NPC1 (0.55) | KITFLT3BTKKDRNPC1 | |
| SCHEMBL24233090 | 0.72 | KDR (0.78) | KITFLT3KDRCDK2PLK4 | |
| SCHEMBL25715122 | 0.72 | BTK (0.49) | KITFLT3BTKEGFRKDR | |
| SCHEMBL25715174 | 0.71 | KDR (0.45) | KITFLT3BTKEGFRKDR | |
| SCHEMBL25715709 | 0.70 | BTK (0.48) | KITFLT3BTKEGFRKDR | |
| SCHEMBL25716378 | 0.70 | BTK (0.40) | KITFLT3BTKEGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104035-A1 | SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 英矽智能科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |