Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.42 |
| ▸ | FEN1 | P39748 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 11/20 | 0.39 |
| ▸ | KIT | P10721 | 5/20 | 0.39 |
| ▸ | FLT3 | P36888 | 5/20 | 0.39 |
| ▸ | LCK | P06239 | 4/20 | 0.39 |
| ▸ | CSF1R | P07333 | 4/20 | 0.39 |
| ▸ | LYN | P07948 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | FLT1 | P17948 | 4/20 | 0.39 |
| ▸ | FLT4 | P35916 | 4/20 | 0.39 |
| ▸ | BLK | P51451 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25715301 | 0.90 | KDR (0.38) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL25716804 | 0.90 | FGFR1 (0.48) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL25716455 | 0.90 | EGFR (0.39) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL25718413 | 0.83 | ALOX5AP (0.41) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL25715151 | 0.81 | BTK (0.40) | FGFR1KDRKITFLT3LCK | |
| SCHEMBL25715211 | 0.79 | LCK (0.36) | KDRKITFLT3LCKCSF1R | |
| SCHEMBL25716378 | 0.78 | BTK (0.40) | FGFR4KDRKITFLT3LCK | |
| SCHEMBL25716441 | 0.77 | LCK (0.36) | FGFR4KDRKITFLT3LCK | |
| SCHEMBL25714979 | 0.77 | BTK (0.46) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24772972 | 0.75 | FGFR4 (0.53) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104035-A1 | SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 英矽智能科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |