Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.57 |
| ▸ | MTOR | P42345 | 11/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25270780 | 0.84 | PIK3CA (0.57) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL258487 | 0.76 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL25720286 | 0.74 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL30986787 | 0.74 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL25228692 | 0.72 | PIK3CA (0.52) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL30308924 | 0.72 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL25232064 | 0.71 | KDM4E (0.49) | PIK3CAPIK3CGALOX15ALDH1A1KDM4E | |
| SCHEMBL9293847 | 0.71 | MAPT (0.45) | ALOX15MAPK1ALDH1A1KDM4EHPGD | |
| SCHEMBL25735294 | 0.70 | ALDH1A1 (0.36) | PIK3CAMTORPIK3CGPIK3R1ALDH1A1 | |
| SCHEMBL16094600 | 0.69 | PIK3CA (0.60) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208964-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | YUMANITY THERAPEUTICS, INC. | 2024-06-27 | — | — | US | disclosed |
| US-20240208964-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | YUMANITY THERAPEUTICS, INC. | 2024-06-27 | — | — | US | disclosed |
| WO-2023107592-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208964-A1 | PYRIDOPYRIMIDINES AND METHODS OF THEIR USE | PNPO, DPYD, PYGB | PIK3CA 3369/4885MTOR 4255/4885PIK3CD 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.