Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572016 | 0.83 | MET (0.68) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL2569522 | 0.80 | MET (0.71) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL2574066 | 0.79 | MET (0.56) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL2572670 | 0.78 | MET (0.56) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL2566584 | 0.78 | MET (0.70) | METPDE3BPDE3A | |
| SCHEMBL2569722 | 0.78 | MET (0.61) | MET | |
| SCHEMBL2572904 | 0.76 | MET (0.49) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL2013882 | 0.75 | MET (0.72) | METCYP2C9PDE3BPDE3APDE10A | |
| SCHEMBL2573902 | 0.73 | PSEN1 (0.47) | MET | |
| SCHEMBL2572431 | 0.73 | MET (0.47) | METCYP2C9PDE3BPDE3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018383-B1 | TRIAZOLOPYRAZINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS | PFIZER PROD INC (US) | 2011-11-09 | — | — | EP | claimed |