Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 19/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2569624 | 0.80 | MET (0.73) | MET | |
| SCHEMBL2566584 | 0.74 | MET (0.70) | MET | |
| SCHEMBL2573970 | 0.74 | MET (0.69) | MET | |
| SCHEMBL2572016 | 0.73 | MET (0.68) | MET | |
| SCHEMBL2572265 | 0.73 | MET (0.48) | MET | |
| SCHEMBL2575215 | 0.73 | MET (0.47) | MET | |
| SCHEMBL2569722 | 0.72 | MET (0.61) | PSEN1PSEN2KCNH2APH1BNCSTN | |
| SCHEMBL2574066 | 0.71 | MET (0.56) | MET | |
| SCHEMBL2572670 | 0.71 | MET (0.56) | MET | |
| SCHEMBL2013882 | 0.69 | MET (0.72) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018383-B1 | TRIAZOLOPYRAZINE DERIVATIVES USEFUL AS ANTI-CANCER AGENTS | PFIZER PROD INC (US) | 2011-11-09 | — | — | EP | claimed |