Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | FPGS | Q05932 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25730752 | 0.91 | DHFR (0.39) | DHFRTYMSFPGS | |
| SCHEMBL24344221 | 0.87 | DHFR (0.40) | DHFR | |
| SCHEMBL25301066 | 0.80 | DHFR (0.48) | DHFRTYMSFPGS | |
| SCHEMBL25301067 | 0.80 | DHFR (0.48) | DHFRTYMSFPGS | |
| SCHEMBL25725435 | 0.78 | DHFR (0.40) | DHFR | |
| SCHEMBL30400568 | 0.78 | DHFR (0.40) | DHFR | |
| SCHEMBL24343802 | 0.76 | TDP1 (0.40) | DHFR | |
| SCHEMBL31476915 | 0.76 | DHFR (0.56) | DHFRTYMS | |
| SCHEMBL24344220 | 0.73 | DHFR (0.35) | DHFRTYMSFPGS | |
| SCHEMBL25171613 | 0.72 | DHFR (0.48) | DHFRTYMSFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144211-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230144211-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | DHFR, FOLR1, MTHFD2 | DHFR 1/4885TYMS 39/4885FPGS 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.