SCHEMBL25730830

SCHEMBL25730830

COC(=O)[C@H](CCCNC(=O)c1ccc(NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)C=CC2=O)C(C)C)cc1-c1nnn[nH]1)NC(=O)c1ccc(COc2cnc3nc(N)nc(N)c3n2)cc1O

nearest known ligand 0.34

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ FAP Q12884 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25167003 0.89 DHFR (0.38) —
SCHEMBL30492196 0.89 DHFR (0.38) —
SCHEMBL25167002 0.89 DHFR (0.38) —
SCHEMBL25730829 0.88 KDM4E (0.32) —
SCHEMBL30492198 0.81 DHFR (0.34) —
SCHEMBL25730826 0.81 DHFR (0.34) —
SCHEMBL25731882 0.81 DHFR (0.39) —
SCHEMBL25730684 0.81 FAP (0.31) FAP
SCHEMBL24343466 0.79 DHFR (0.43) —
SCHEMBL30311369 0.77 DHFR (0.48) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230144211-A1 ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES BYONDIS B.V. (NL) 2023-05-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230144211-A1 ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES DHFR, FOLR1, MTHFD2 FAP 2086/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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