Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217162 | 0.93 | HSP90AA1 (0.34) | TRIM24TRIM33ALDH1A1HPGDMEN1 | |
| SCHEMBL60542 | 0.84 | — | — | |
| SCHEMBL13547376 | 0.83 | TRIM24 (0.43) | TRIM24TRIM33ALDH1A1HPGDMEN1 | |
| Ammonia Solution, Strong SCHEMBL27931519 | 0.82 | HSP90AA1 (0.42) | HPGDKMT2AHSP90AA1TP53NPC1 | |
| SCHEMBL4697869 | 0.79 | TRIM24 (0.43) | TRIM24TRIM33ALDH1A1HPGDKMT2A | |
| SCHEMBL784996 | 0.76 | TRIM24 (0.39) | TRIM24TRIM33ALDH1A1HPGDKMT2A | |
| SCHEMBL11726510 | 0.74 | TSHR (0.38) | TRIM24TRIM33ALDH1A1HPGDHSP90AA1 | |
| SCHEMBL1304158 | 0.74 | NOTUM (0.44) | ALDH1A1HSP90AA1TDP1 | |
| SCHEMBL670641 | 0.73 | — | — | |
| SCHEMBL76824 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240010650-A1 | TETRACYCLIC COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. | 2024-01-11 | — | — | US | disclosed |
| US-11697652-B2 | Tetracyclic compounds and uses thereof | GILEAD SCIENCES, INC. (US) | 2023-07-11 | — | — | US | disclosed |
| EP-4110783-A1 | TETRACYCLIC COMPOUNDS FOR TREATING HIV INFECTION | GILEAD SCIENCES, INC. (US) | 2023-01-04 | — | — | EP | disclosed |
| US-20210284642-A1 | TETRACYCLIC COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. | 2021-09-16 | — | — | US | disclosed |
| WO-2012170845-A2 | METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | HEFFERNAN MICHELE L R (US) | 2012-12-13 | — | — | WO | disclosed |
| EP-2384328-A1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR PREPARING THEM | Boehringer Ingelheim International GmbH (DE) | 2011-11-09 | — | — | EP | disclosed |
| WO-2010060952-A1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11697652-B2 | Tetracyclic compounds and uses thereof | HAVCR2, PAICS, CCR5 | TRIM24 4263/4885TRIM33 3133/4885ALDH1A1 1950/4885 |
| US-20210284642-A1 | TETRACYCLIC COMPOUNDS AND USES THEREOF | HAVCR2, PAICS, CCR5 | TRIM24 4263/4885TRIM33 3133/4885ALDH1A1 1950/4885 |
| US-20240010650-A1 | TETRACYCLIC COMPOUNDS AND USES THEREOF | HAVCR2, PAICS, CCR5 | TRIM24 4263/4885TRIM33 3133/4885ALDH1A1 1950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.