Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | DAO | P14920 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15100864 | 0.82 | MEN1 (0.52) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL257361 | 0.82 | CES2 (0.49) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL11533299 | 0.78 | KMT2A (0.55) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL11536164 | 0.77 | CYP2C9 (0.57) | ALDH1A1MAPTKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL11536171 | 0.76 | HPGD (0.44) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL835069 | 0.76 | DAO (1.00) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL15100846 | 0.75 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL6495865 | 0.73 | KMT2A (0.66) | ALDH1A1MAPTKMT2AMEN1DAO | |
| SCHEMBL11403347 | 0.73 | ALDH1A1 (0.66) | ALDH1A1MAPTKMT2AMEN1DAO | |
| SCHEMBL257493 | 0.73 | MEN1 (0.49) | ALDH1A1MAPTKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895552-B2 | Cyclic amide derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8895552-B2 | Cyclic amide derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2014-11-25 | — | — | US | disclosed |
| US-20130217692-A1 | CYCLIC AMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-08-22 | — | — | US | disclosed |
| US-20130217692-A1 | CYCLIC AMIDE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-08-22 | — | — | US | disclosed |
| EP-2612848-A1 | CYCLIC AMIDE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029942-A1 | CYCLIC AMIDE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2012-03-08 | — | — | WO | disclosed |
| US-20060069272-A1 | Process for preparing 2,5-disubstituted 3-alkylthiophenes | ARCHIMICA S.R.L. (IT) | 2006-03-30 | — | — | US | disclosed |
| EP-1554266-B1 | PROCESS FOR PREPARING 2,5-DISUBSTITUTED 3-ALKYLTHIOPHENES | CLARIANT LSM ITALIA SPA (IT) | 2006-03-22 | — | — | EP | disclosed |
| EP-1554266-A1 | PROCESS FOR PREPARING 2,5-DISUBSTITUTED 3-ALKYLTHIOPHENES | Clariant Life Science Molecules (Italia) S.p.A. (IT) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035562-A1 | PROCESS FOR PREPARING 2,5-DISUBSTITUTED 3-ALKYLTHIOPHENES | CLARIANT LIFE SCIENCE MOLECULES (ITALIA) S.P.A. (IT) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217692-A1 | CYCLIC AMIDE DERIVATIVE | HDAC10, H1-10, H1-0 | ALDH1A1 538/4885MAPT 3973/4885KDM4E 2413/4885 |
| US-20060069272-A1 | Process for preparing 2,5-disubstituted 3-alkylthiophenes | AGPAT5, AGPAT2, GNPAT | ALDH1A1 480/4885MAPT 1238/4885KDM4E 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.