Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 7/20 | 0.34 |
| ▸ | HTR2A | P28223 | 6/20 | 0.34 |
| ▸ | HTR2B | P41595 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5917470 | 0.70 | POLB (0.49) | POLBHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL692320 | 0.69 | DRD2 (0.41) | POLBHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL2017462 | 0.67 | HTR2A (0.39) | POLBHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL2018737 | 0.65 | SOS1 (0.41) | POLBHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL693038 | 0.65 | POLB (0.40) | POLBHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL2558862 | 0.63 | HTR2C (0.45) | POLBHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL692247 | 0.63 | HTR2C (0.45) | POLBHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL11464265 | 0.63 | HTR2C (0.52) | HTR2CHTR2AHTR2BDRD2DRD4 | |
| SCHEMBL11829920 | 0.63 | HTR2C (0.47) | POLBHTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL14714357 | 0.63 | POLB (0.35) | POLBHTR2CHTR2AHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | claimed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | claimed |