Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2575231 | 0.69 | KDM4E (0.35) | ALDH1A1KDM4E | |
| SCHEMBL25704818 | 0.68 | ALOX5 (0.34) | HTT | |
| SCHEMBL29599802 | 0.65 | MAPT (0.52) | ALDH1A1MAPTHTTGPR55 | |
| SCHEMBL4500876 | 0.64 | TSHR (0.41) | — | |
| SCHEMBL24969145 | 0.64 | ESR1 (0.39) | MAPTHTTKDM4E | |
| SCHEMBL6786858 | 0.64 | ALOX5 (0.38) | HTT | |
| SCHEMBL10784280 | 0.64 | MAPT (0.48) | ALDH1A1MAPTHTTGPR55 | |
| SCHEMBL23460351 | 0.64 | CYP1A2 (0.32) | HTT | |
| SCHEMBL2575229 | 0.63 | MAPT (0.34) | ALDH1A1MAPTHTTKDM4E | |
| SCHEMBL29178999 | 0.63 | OPRM1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643325-A1 | SPIRO-AMINO-IMIDAZOLONE AND SPIRO-AMINO-DIHYDRO-PYRIMIDINONE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012071279-A1 | SPIRO-AMINO-IMIDAZOLONE AND SPIRO-AMINO-DIHYDRO-PYRIMIDINONE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2012-05-31 | — | — | WO | disclosed |
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |