Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6467492 | 0.86 | KMT2A (0.39) | KMT2AHPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27487172 | 0.83 | KMT2A (0.43) | KMT2AHPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8113147 | 0.83 | KMT2A (0.43) | KMT2AHPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27502344 | 0.82 | KMT2A (0.42) | KMT2AHPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27586732 | 0.81 | ALOX5 (0.47) | KMT2AHPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11148614 | 0.81 | KMT2A (0.63) | KMT2AHPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL174224 | 0.80 | KMT2A (0.62) | KMT2AHPGDALDH1A1TSHRMAPT | |
| SCHEMBL16277713 | 0.80 | KMT2A (0.33) | KMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL8626825 | 0.79 | ALDH1A1 (0.42) | KMT2AHPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL25984798 | 0.78 | NR3C2 (0.53) | KMT2AHPGDALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563795-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | MethylGene Inc. (CA) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011127567-A1 | INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY | METHYLGENE INC. (CA) | 2011-10-20 | — | — | WO | disclosed |
| CN-1386095-A | Imaging media containing heat developable photosensitive microcapsule | SIPIX IMAGING INC (US) | 2002-12-18 | — | — | CN | disclosed |