SCHEMBL25754623

SCHEMBL25754623

CC#CC(=O)[C@@H]1C[C@H](CN2CCCCC2)N1

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.31
MAPT P10636 1/20 0.31
CHRM5 P08912 1/20 0.31
ADRA2C P18825 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25754625 1.00 DPP4 (0.31) DPP4MAPTCHRM5ADRA2C
SCHEMBL25754617 0.72 CHRM5 (0.35) CHRM5ADRA2C
SCHEMBL25754622 0.71 CHRM5 (0.34) CHRM5ADRA2C
SCHEMBL25754627 0.70 MEN1 (0.32) CHRM5ADRA2C
SCHEMBL25754626 0.70 MEN1 (0.32) CHRM5ADRA2C
SCHEMBL25754635 0.69 CHRM5 (0.32) CHRM5ADRA2C
SCHEMBL27738377 0.65 CHRM5 (0.38) CHRM5ADRA2C
SCHEMBL9734363 0.61 CHRM2 (0.39) DPP4
SCHEMBL9734361 0.61 CHRM2 (0.39) DPP4
SCHEMBL7840193 0.60 ADRA2C (0.48) MAPTCHRM5ADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM EUBULUS BIOTHERAPEUTICS (HONG KONG) LIMITED (HK) 2023-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM UCHL3, UBE2L3, ADAM33 DPP4 1068/4885MAPT 1198/4885CHRM5 4717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.