SCHEMBL25754712

SCHEMBL25754712

CC#CC(=O)COCCNCCN1CCCCC1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.38
NPC1 O15118 1/20 0.37
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA9 Q16790 2/20 0.36
ALDH1A1 P00352 3/20 0.35
KDM4E B2RXH2 3/20 0.35
POLB P06746 2/20 0.35
MEN1 O00255 1/20 0.35
CARM1 Q86X55 1/20 0.34
PRMT6 Q96LA8 1/20 0.34
PRMT8 Q9NR22 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
MAPT P10636 1/20 0.33
DPP7 Q9UHL4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25754725 0.92 KMT2A (0.36) KMT2ANPC1CA12CA1CA2
SCHEMBL25754691 0.81 NPC1 (0.41) KMT2ANPC1CA12CA1CA2
SCHEMBL25754612 0.81 HRH3 (0.43) KMT2AALDH1A1KDM4EMEN1
SCHEMBL25754605 0.81 HRH3 (0.43) KMT2AALDH1A1KDM4EMEN1
SCHEMBL25754754 0.81 KMT2A (0.36) KMT2ANPC1CA12CA1CA2
SCHEMBL25754758 0.81 HRH3 (0.39) KDM4EPOLBMAPT
SCHEMBL25754717 0.79 HRH3 (0.40) KDM4EPOLBMAPT
SCHEMBL25754752 0.75 SMN1; SMN2 (0.38) ALDH1A1KDM4EPOLBMAPT
SCHEMBL25754658 0.74 CARM1 (0.38) KMT2ANPC1CA12CA1CA2
SCHEMBL25754320 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM EUBULUS BIOTHERAPEUTICS (HONG KONG) LIMITED (HK) 2023-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM UCHL3, UBE2L3, ADAM33 KMT2A 1974/4885NPC1 4242/4885CA12 1438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.