SCHEMBL25754861

SCHEMBL25754861

CNC(=O)CCCCCCCCc1c[nH]nn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TBXAS1 P24557 1/20 0.40
NAMPT P43490 1/20 0.37
MTNR1A P48039 1/20 0.36
MPO P05164 1/20 0.36
HDAC1 Q13547 13/20 0.35
FAAH O00519 1/20 0.34
HDAC2 Q92769 2/20 0.33
ALOX5 P09917 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
P2RY12 Q9H244 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25754858 0.89 GAA (0.34) TBXAS1NAMPTMTNR1AMPOHDAC1
SCHEMBL25754859 0.88 GAA (0.36) TBXAS1NAMPTMTNR1AMPOHDAC1
SCHEMBL25755156 0.88 NAMPT (0.34) TBXAS1NAMPTMPOHDAC1HDAC2
SCHEMBL25755165 0.83 CYP3A4 (0.34) TBXAS1NAMPTHDAC1HDAC2
SCHEMBL7544559 0.83 PAOX (0.37) TBXAS1
SCHEMBL5534335 0.81 TBXAS1 (0.45) TBXAS1
SCHEMBL8464935 0.81 TBXAS1 (0.45) TBXAS1
SCHEMBL5537212 0.81 TBXAS1 (0.45) TBXAS1
SCHEMBL29625440 0.81 PAOX (0.34) HDAC1
SCHEMBL8467504 0.81 TBXAS1 (0.35) TBXAS1MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM EUBULUS BIOTHERAPEUTICS (HONG KONG) LIMITED (HK) 2023-07-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210999-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM UCHL3, UBE2L3, ADAM33 TBXAS1 3771/4885NAMPT 3233/4885MTNR1A 2257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.