Sugi Predict

Sugi Predict / Compounds / SCHEMBL25756617

SCHEMBL25756617

SCHEMBL25756617

CCN1C(=O)C(=O)c2ccc(NC(=O)OC(C)(C)C)c(OC)c21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 1/20 0.40
▸ CNR2 P34972 1/20 0.38
▸ MAPT P10636 3/20 0.37
▸ TP53 P04637 1/20 0.37
▸ ALDH1A1 P00352 5/20 0.36
▸ BRD4 O60885 3/20 0.35
▸ HTT P42858 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ CES1 P23141 1/20 0.34
▸ KCNQ4 P56696 2/20 0.34
▸ KCNQ5 Q9NR82 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ PARK7 Q99497 1/20 0.33
▸ PIK3CD O00329 1/20 0.33
▸ ABL1 P00519 1/20 0.33
▸ EGFR P00533 1/20 0.33
▸ KDR P35968 1/20 0.33
▸ PIK3CA P42336 1/20 0.33
▸ PIK3CG P48736 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25756589 0.74 CYP1B1 (0.46) MAPTTP53ALDH1A1HTTHSD17B10
SCHEMBL25756618 0.72 MEN1 (0.46) MAPTTP53ALDH1A1HTTHSD17B10
SCHEMBL4038402 0.70 ALDH1A1 (0.46) MAPTALDH1A1HTTHSD17B10MEN1
SCHEMBL30895067 0.69 ACSS2 (0.36) CNR2MAPTTP53PIK3CDABL1
SCHEMBL25754179 0.69 ACSS2 (0.36) CNR2MAPTTP53PIK3CDABL1
SCHEMBL25672474 0.69 MAPK1 (0.39) CNR2MAPTALDH1A1PIK3CDABL1
SCHEMBL25754005 0.69 MAPT (0.38) CNR2MAPTBRD4PIK3CDABL1
SCHEMBL21468506 0.69 KCNQ4 (0.40) HTTKCNQ4KCNQ5MEN1KMT2A
SCHEMBL31017417 0.68 ACSS2 (0.42) MAPTALDH1A1BRD4KMT2ABRD9
SCHEMBL25754261 0.68 ACSS2 (0.42) MAPTALDH1A1BRD4KMT2ABRD9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO LTD (CN) 2025-04-10 — — US disclosed
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-10-29 — — US disclosed
CN-118401516-A TYK2 inhibitors, compositions and methods thereof 凌科药业(杭州)有限公司 2024-07-26 — — CN disclosed
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-04-18 — — US disclosed
WO-2023109954-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2023-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 RORC 587/4885CNR2 3169/4885MAPT 908/4885
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 RORC 587/4885CNR2 3169/4885MAPT 908/4885
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof TYK2, JAK2, JAK1 RORC 587/4885CNR2 3169/4885MAPT 908/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.