Sugi Predict

Sugi Predict / Compounds / SCHEMBL25756944

SCHEMBL25756944

SCHEMBL25756944

CCCc1cnn2ccc(NC(=O)OC(C)(C)C)c(OC)c12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PCSK9 Q8NBP7 1/20 0.35
▸ MAPKAPK2 P49137 2/20 0.35
▸ CNR2 P34972 1/20 0.34
▸ SREBF2 Q12772 1/20 0.34
▸ IDO1 P14902 2/20 0.33
▸ CYP17A1 P05093 2/20 0.33
▸ KDM4E B2RXH2 2/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ CTSS P25774 1/20 0.32
▸ CTSK P43235 1/20 0.32
▸ METAP1 P53582 1/20 0.32
▸ GPR139 Q6DWJ6 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ BRD9 Q9H8M2 1/20 0.31
▸ ATR Q13535 1/20 0.31
▸ DGAT1 O75907 1/20 0.31
▸ HDAC3 O15379 1/20 0.31
▸ HDAC8 Q9BY41 1/20 0.31
▸ NCOR2 Q9Y618 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30895044 0.92 PCSK9 (0.36) PCSK9MAPKAPK2CNR2IDO1CYP17A1
SCHEMBL25757532 0.89 PCSK9 (0.36) PCSK9IDO1CYP17A1KDM4EALDH1A1
SCHEMBL27199662 0.85 ALDH1A1 (0.35) KDM4EALDH1A1LMNAHSD17B10
SCHEMBL25757534 0.85 EGLN2 (0.34) PCSK9MAPKAPK2IDO1KDM4EALDH1A1
SCHEMBL25757533 0.84 IDO1 (0.33) PCSK9IDO1METAP1ATR
SCHEMBL30895110 0.83 DGAT1 (0.35) PCSK9IDO1CYP17A1METAP1BRD9
SCHEMBL30895038 0.83 ITGA4 (0.36) PCSK9IDO1KDM4EALDH1A1BRD9
SCHEMBL25756943 0.83 IDO1 (0.37) PCSK9CNR2IDO1CYP17A1KDM4E
SCHEMBL25757793 0.82 NR1I2 (0.34) PCSK9IDO1METAP1BRD9ATR
SCHEMBL25757792 0.81 ATR (0.35) PCSK9IDO1KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO LTD (CN) 2025-04-10 — — US disclosed
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-10-29 — — US disclosed
CN-118401516-A TYK2 inhibitors, compositions and methods thereof 凌科药业(杭州)有限公司 2024-07-26 — — CN disclosed
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-04-18 — — US disclosed
WO-2023109954-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2023-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 PCSK9 1236/4885MAPKAPK2 64/4885CNR2 3169/4885
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 PCSK9 1236/4885MAPKAPK2 64/4885CNR2 3169/4885
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof TYK2, JAK2, JAK1 PCSK9 1236/4885MAPKAPK2 64/4885CNR2 3169/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.