Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 13/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25757417 | 0.85 | TUBB4A (0.52) | IDH1MEN1MAPTHTTKMT2A | |
| SCHEMBL25757383 | 0.77 | IDH1 (0.50) | IDH1 | |
| SCHEMBL23846671 | 0.77 | MAPT (0.60) | MEN1MAPTHTTKMT2AGPR27 | |
| SCHEMBL23846356 | 0.77 | IDH1 (0.48) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL23846612 | 0.76 | MAPT (0.51) | MEN1MAPTHTTKMT2ASMO | |
| SCHEMBL23846613 | 0.75 | MEN1 (0.51) | IDH1MEN1MAPTKMT2AGPR27 | |
| SCHEMBL23846617 | 0.74 | MAPT (0.56) | IDH1MEN1MAPTKMT2AGPR27 | |
| SCHEMBL25759559 | 0.74 | MAPT (0.43) | IDH1MEN1MAPTHTTKMT2A | |
| SCHEMBL23846623 | 0.74 | SCN10A (0.51) | IDH1MEN1MAPTHTTKMT2A | |
| SCHEMBL25757359 | 0.73 | KMT2A (0.49) | MEN1MAPTHTTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, TP53BP1 | IDH1 442/4885MEN1 3902/4885MAPT 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.