Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25765320 | 0.88 | NPBWR1 (0.49) | ALDH1A1LMNASMN1; SMN2PDE4DKMT2A | |
| SCHEMBL21935049 | 0.79 | NPBWR1 (0.46) | ALDH1A1LMNASMN1; SMN2KMT2AALOX15 | |
| SCHEMBL4295664 | 0.78 | KMT2A (0.56) | ALDH1A1LMNASMN1; SMN2KMT2AALOX15 | |
| SCHEMBL7465575 | 0.76 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2PDE4DKMT2APDE4B | |
| SCHEMBL14454774 | 0.75 | NPBWR1 (0.53) | ALDH1A1LMNASMN1; SMN2KMT2AALOX15 | |
| SCHEMBL2085500 | 0.75 | ATM (0.47) | ALDH1A1LMNASMN1; SMN2PDE4DKMT2A | |
| SCHEMBL25765315 | 0.74 | NPBWR1 (0.46) | ALDH1A1LMNASMN1; SMN2PDE4DKMT2A | |
| SCHEMBL398334 | 0.74 | ALDH1A1 (0.48) | ALDH1A1LMNASMN1; SMN2KMT2AALOX15 | |
| SCHEMBL12843980 | 0.73 | ALOX15 (0.52) | ALDH1A1LMNASMN1; SMN2KMT2AALOX15 | |
| SCHEMBL20502220 | 0.73 | PDE4D (0.74) | ALDH1A1PDE4DKMT2APDE4BNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212157-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212157-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, ABCC5, ABCC1 | ALDH1A1 1738/4885LMNA 4394/4885SMN1; SMN2 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.