SCHEMBL257702

SCHEMBL257702

Cc1nn2c(-c3ccc(F)c(F)c3)cc(N3CCC[C@H]3CO)nc2c1-c1ccc(C(F)F)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 1/20 0.36
SCN9A Q15858 1/20 0.36
EGLN2 Q96KS0 2/20 0.36
HPGD P15428 2/20 0.34
KDM4E B2RXH2 1/20 0.34
USP2 O75604 1/20 0.34
ALDH1A1 P00352 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
HSD17B10 Q99714 1/20 0.34
SOS1 Q07889 2/20 0.34
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34
BCL6 P41182 1/20 0.34
KMT2A Q03164 2/20 0.34
TP53 P04637 1/20 0.34
POLB P06746 1/20 0.34
ITGB2 P05107 2/20 0.34
ICAM1 P05362 2/20 0.34
ITGAL P20701 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15020689 0.92 FPR2 (0.42) FPR2SCN9AEGLN2HPGDKDM4E
SCHEMBL15020743 0.91 LMNA (0.40) FPR2SCN9AEGLN2HPGDKDM4E
SCHEMBL257396 0.91 LMNA (0.40) FPR2SCN9AEGLN2HPGDKDM4E
SCHEMBL15020602 0.91 FPR2 (0.38) FPR2SCN9AEGLN2HPGDKDM4E
SCHEMBL15020605 0.91 FPR2 (0.38) FPR2SCN9AEGLN2HPGDKDM4E
SCHEMBL256935 0.91 FPR2 (0.38) FPR2SCN9AEGLN2HPGDKDM4E
SCHEMBL15020893 0.91 TP53 (0.43) FPR2SCN9AHPGDKDM4EUSP2
SCHEMBL15020732 0.89 MAPT (0.38) FPR2SCN9AEGLN2HPGDKDM4E
SCHEMBL15021446 0.88 MAPT (0.45) FPR2SCN9AMAPK1ADORA2AADORA1
SCHEMBL257511 0.88 MAPT (0.45) FPR2SCN9AMAPK1ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8975264-B2 Compound acting as a cannabinoid receptor-1 inhibitor AMOREPACIFIC CORPORATION (KR) 2015-03-10 US disclosed
US-20130158025-A1 NOVEL COMPOUND ACTING AS A CANNABINOID RECEPTOR-1 INHIBITOR AMOREPACIFIC CORPORATION (KR) 2013-06-20 US disclosed
WO-2012030170-A2 NOVEL COMPOUND ACTING AS A CANNABINOID RECEPTOR-1 INHIBITOR (주)아모레퍼시픽 (KR) 2012-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130158025-A1 NOVEL COMPOUND ACTING AS A CANNABINOID RECEPTOR-1 INHIBITOR CNR1, CNR2, GPR18 FPR2 2908/4885SCN9A 615/4885EGLN2 1186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.