SCHEMBL2577973

SCHEMBL2577973

COc1ccc2c(c1)C1(N=C(c3cc(F)cc(Cl)c3)N(C)C1=O)c1ccccc1O2

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 20/20 0.48
CTSD P07339 10/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7710636 0.82 BACE1 (0.69) BACE1CTSD
SCHEMBL2576404 0.79 BACE1 (0.44) BACE1CTSD
SCHEMBL2576401 0.73 BACE1 (0.73) BACE1CTSD
SCHEMBL2574031 0.73 BACE1 (0.56) BACE1CTSD
SCHEMBL2573158 0.71 BACE1 (0.67) BACE1CTSD
SCHEMBL7713140 0.71 BACE1 (0.61) BACE1CTSD
SCHEMBL7711676 0.70 BACE1 (0.78) BACE1CTSD
SCHEMBL2572696 0.70 BACE1 (0.79) BACE1CTSD
SCHEMBL2570745 0.70 BACE1 (0.42) BACE1CTSD
SCHEMBL2574299 0.69 BACE1 (0.44) BACE1CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011130741-A1 COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES ARRAY BIOPHARMA INC. (US) 2011-10-20 WO disclosed