Diacerein

Diacerein

SCHEMBL25784

CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 9/20 1.00
ALDH1A1 P00352 5/20 1.00
KDM4E B2RXH2 4/20 1.00
HPGD P15428 3/20 1.00
MEN1 O00255 2/20 1.00
LMNA P02545 2/20 1.00
HSP90AA1 P07900 2/20 1.00
HSP90AB1 P08238 2/20 1.00
MAPT P10636 2/20 1.00
CASP7 P55210 2/20 1.00
KMT2A Q03164 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
FTO Q9C0B1 2/20 1.00
MAPK1 P28482 2/20 1.00
ABCC4 O15439 1/20 1.00
USP2 O75604 1/20 1.00
TP53 P04637 1/20 1.00
CHRM2 P08172 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diacerein SCHEMBL29944894 1.00 TTR (1.00) TTRALDH1A1KDM4EHPGDMEN1
Diacerein SCHEMBL5051685 1.00 TTR (1.00) TTRALDH1A1KDM4EHPGDMEN1
Diacerein SCHEMBL29423907 1.00 TTR (1.00) TTRALDH1A1KDM4EHPGDMEN1
Diacerein SCHEMBL7438555 0.99 TTR (0.97) TTRALDH1A1KDM4EHPGDMEN1
Diacerein SCHEMBL5078956 0.99 TTR (0.97) TTRALDH1A1KDM4EHPGDMEN1
Diacerein SCHEMBL787907 0.99 TTR (0.97) TTRALDH1A1KDM4EHPGDMEN1
Diacerein SCHEMBL2326532 0.93 TTR (0.86) TTRALDH1A1KDM4EHPGDMEN1
SCHEMBL23655432 0.92 TTR (0.84) TTRALDH1A1KDM4EHPGDMEN1
Diacerein SCHEMBL5712120 0.92 MEN1 (0.84) TTRALDH1A1KDM4EHPGDMEN1
SCHEMBL16549421 0.90 TTR (0.82) TTRALDH1A1KDM4EHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6187 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118184604-B Rhein-piperazine-sulfonamide hybrid, and preparation method and application thereof 宁夏大学 2026-05-19 CN claimed
US-20260092050-A1 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF RAPT THERAPEUTICS INC (US) 2026-04-02 US claimed
EP-4680203-A1 COMPOSITIONS FOR SUSTAINED RELEASE OF POORLY SOLUBLE ACTIVE INGREDIENTS Prolevi Bio AB (SE) 2026-01-21 EP claimed
EP-3699174-B1 COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME ILAB (KR) 2025-11-12 EP claimed
EP-4640714-A2 METHODS FOR ASSESSING RISK OF DEVELOPING A VIRAL DISEASE USING A GENETIC TEST PML Screening, LLC (US) 2025-10-29 EP claimed
EP-4636687-A1 METHOD AND DEVICE FOR INSPECTING 3-DIMENSIONAL OBJECTS ISRA VISION GMBH (DE) 2025-10-22 EP claimed
EP-3713918-B1 SULFASALAZINE SALTS, PRODUCTION PROCESSES AND USES MEDAC GES FUER KLINISCHE SPEZIALPRAEPARATE MBH (DE) 2025-07-23 EP claimed
WO-2025137471-A1 DECELLULARIZED PLACENTA EXTRACELLULAR MATRIX AND USES THEREOF CELULARITY INC. (US) 2025-06-26 WO claimed
US-20250177565-A1 METHODS AND MATERIALS FOR INHIBITING/PREVENTING THE TRAFFICKING OF MONOCYTES TO THE CENTRAL NERVOUS SYSTEM DARTMOUTH COLLEGE (US) 2025-06-05 US claimed
US-20250122208-A1 CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF RAPT THERAPEUTICS, INC. 2025-04-17 US claimed
WO-1992013864-A1 ACYLAMINO-ALKYLIDEN-HYDROXY-BISPHOSPHONIC ACIDS USEFUL IN THE THERAPY OF OSTEOARTICULAR DISEASES ISTITUTO GENTILI S.P.A. (IT) 1992-08-20 WO claimed
EP-0264989-B1 GALENIC FORMULATIONS FOR ORAL USE OF RHEIN DERIVATIVES WITH DELAYED RELEASE FOR THERAPEUTICAL USE PROTER S.p.A. (IT) 1991-12-18 EP claimed
EP-0243968-B1 DIACETYLRHEIN POTASSIUM SALT AND ITS THERAPEUTICAL USE IN THE TREATMENT OF ARTHRITIS PROTER S.p.A. (IT) 1991-08-21 EP claimed
US-4950687-A Diacetylrhein salts and their therapeutical use in the treatment of arthrosis PROTER S.P.A. (IT) 1990-08-21 US claimed
EP-0371431-A2 Supported drugs with increased dissolution rate, and a process for their preparation VECTORPHARMA INTERNATIONAL S.P.A. (IT) 1990-06-06 EP claimed
EP-0364944-A1 Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate VECTORPHARMA INTERNATIONAL S.P.A. (IT) 1990-04-25 EP claimed
US-4861599-A Galenic formulations for oral use of rhein derivatives with delayed release for therapeutical use PROTER S.P.A. (IT) 1989-08-29 US claimed
EP-0264989-A1 Galenic formulations for oral use of rhein derivatives with delayed release for therapeutical use PROTER S.p.A. (IT) 1988-04-27 EP claimed
EP-0243968-A2 Diacetylrhein potassium salt and its therapeutical use in the treatment of arthritis PROTER S.p.A. (IT) 1987-11-04 EP claimed
US-4244968-A HYDROXY- AND AMINO-ANTHRAQUINONES PROTER S.P.A. (IT) 1981-01-13 US claimed