Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 9/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.97 |
| ▸ | HPGD | P15428 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.97 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 2/20 | 0.97 |
| ▸ | CASP7 | P55210 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.97 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.97 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.97 |
| ▸ | USP2 | O75604 | 1/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diacerein SCHEMBL5051685 | 0.99 | TTR (1.00) | TTRALDH1A1KDM4EHPGDMEN1 | |
| Diacerein SCHEMBL25784 | 0.99 | TTR (1.00) | TTRALDH1A1KDM4EHPGDMEN1 | |
| Diacerein SCHEMBL29944894 | 0.99 | TTR (1.00) | TTRALDH1A1KDM4EHPGDMEN1 | |
| Diacerein SCHEMBL29423907 | 0.99 | TTR (1.00) | TTRALDH1A1KDM4EHPGDMEN1 | |
| Diacerein SCHEMBL7438555 | 0.97 | TTR (0.97) | TTRALDH1A1KDM4EHPGDMEN1 | |
| Diacerein SCHEMBL5078956 | 0.97 | TTR (0.97) | TTRALDH1A1KDM4EHPGDMEN1 | |
| Diacerein SCHEMBL2326532 | 0.92 | TTR (0.86) | TTRALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL23655432 | 0.91 | TTR (0.84) | TTRALDH1A1KDM4EHPGDMEN1 | |
| Diacerein SCHEMBL5712120 | 0.91 | MEN1 (0.84) | TTRALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL16549421 | 0.89 | TTR (0.82) | TTRALDH1A1KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243968-B1 | DIACETYLRHEIN POTASSIUM SALT AND ITS THERAPEUTICAL USE IN THE TREATMENT OF ARTHRITIS | PROTER S.p.A. (IT) | 1991-08-21 | — | — | EP | claimed |
| EP-1913940-B1 | RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS | CONG XIAODONG (CN) | 2018-11-21 | — | — | EP | disclosed |
| EP-3207921-A1 | RHEIN OR DIACEREIN COMPOSITIONS | Wockhardt Limited (IN) | 2017-08-23 | — | — | EP | disclosed |
| US-9181172-B2 | Rhein conjugates, preparation method thereof and their uses in producing medicines for treating diabetic nephrosis, intestinal adhesion and osteoarthritis | CONG XIAODONG (CN) | 2015-11-10 | — | — | US | disclosed |
| US-9119819-B2 | Oral liquid compositions of rhein or diacerein | WOCKHARDT LTD. (IN) | 2015-09-01 | — | — | US | disclosed |
| EP-2224914-B1 | DIACEREIN COMPOSITIONS | WOCKHARDT LTD (IN) | 2015-01-21 | — | — | EP | disclosed |
| US-20140302126-A1 | Rhein or diacerein compositions | WOCKHARDT RESEARCH CENTRE (IN) | 2014-10-09 | — | — | US | disclosed |
| US-8821924-B2 | Rhein or diacerein compositions | WOCKHARDT LTD. (IN) | 2014-09-02 | — | — | US | disclosed |
| US-8598232-B2 | Process for the preparation of non-genotoxic diacetylrhein (diacerein) and formulations comprising non-genotoxic diacetylrhein | EVULTIS SA (CH) | 2013-12-03 | — | — | US | disclosed |
| EP-2471515-A2 | Rhein or diacerein compositions | Wockhardt Limited (IN) | 2012-07-04 | — | — | EP | disclosed |
| WO-2009133431-A1 | ORAL LIQUID COMPOSITIONS OF RHEIN OR DIACEREIN | WOCKHARDT RESEARCH CENTRE (IN) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009034409-A2 | PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | WOCKHARDT RESEARCH CENTRE (IN) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034558-A2 | RHEIN OR DIACEREIN COMPOSITIONS | WOCKHARDT RESEARCH CENTRE (IN) | 2009-03-19 | — | — | WO | disclosed |
| US-20080207758-A1 | Reaction product of rhein with bases or amino acids; antidiabetic agents; gastrointestinal disorders; antiarthritic agents | CONG XIAODONG | 2008-08-28 | — | — | US | disclosed |
| EP-1913940-A1 | RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS | Jiangsu Lianchuang Pharmaceutical Technology Co. (CN) | 2008-04-23 | — | — | EP | disclosed |
| EP-0243968-B1 | DIACETYLRHEIN POTASSIUM SALT AND ITS THERAPEUTICAL USE IN THE TREATMENT OF ARTHRITIS | PROTER S.p.A. (IT) | 1991-08-21 | — | — | EP | disclosed |
| EP-0243968-B1 | DIACETYLRHEIN POTASSIUM SALT AND ITS THERAPEUTICAL USE IN THE TREATMENT OF ARTHRITIS | PROTER S.p.A. (IT) | 1991-08-21 | — | — | EP | disclosed |
| US-4950687-A | Diacetylrhein salts and their therapeutical use in the treatment of arthrosis | PROTER S.P.A. (IT) | 1990-08-21 | — | — | US | disclosed |
| EP-0243968-A2 | Diacetylrhein potassium salt and its therapeutical use in the treatment of arthritis | PROTER S.p.A. (IT) | 1987-11-04 | — | — | EP | disclosed |
| EP-0243968-A2 | Diacetylrhein potassium salt and its therapeutical use in the treatment of arthritis | PROTER S.p.A. (IT) | 1987-11-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207758-A1 | Reaction product of rhein with bases or amino acids; antidiabetic agents; gastrointestinal disorders; antiarthritic agents | ARGLU1, RO60, CROCC | TTR 907/4885ALDH1A1 3432/4885KDM4E 4607/4885 |
| US-20140302126-A1 | Rhein or diacerein compositions | CERT1, RDX, CD38 | TTR 3464/4885ALDH1A1 3991/4885KDM4E 4364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.