Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.66 |
| ▸ | RAB9A | P51151 | 9/20 | 0.66 |
| ▸ | MAPT | P10636 | 9/20 | 0.66 |
| ▸ | NPC1 | O15118 | 8/20 | 0.66 |
| ▸ | RECQL | P46063 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.66 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856652 | 0.80 | RAB9A (1.00) | SMN1; SMN2RAB9AMAPTNPC1RECQL | |
| SCHEMBL4263699 | 0.78 | MAPT (0.60) | SMN1; SMN2RAB9AMAPTNPC1RECQL | |
| SCHEMBL2581162 | 0.78 | RAB9A (0.58) | SMN1; SMN2RAB9AMAPTNPC1RECQL | |
| SCHEMBL23657497 | 0.76 | MAPT (0.78) | SMN1; SMN2RAB9AMAPTNPC1RECQL | |
| SCHEMBL4259746 | 0.74 | LMNA (0.50) | SMN1; SMN2RAB9AMAPTNPC1RECQL | |
| SCHEMBL2580961 | 0.73 | ALDH1A1 (0.65) | SMN1; SMN2RAB9AMAPTNPC1ALDH1A1 | |
| SCHEMBL4272825 | 0.72 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9AMAPTNPC1RECQL | |
| SCHEMBL4268590 | 0.71 | MAPT (0.58) | SMN1; SMN2RAB9AMAPTNPC1RECQL | |
| SCHEMBL2578771 | 0.70 | HSP90AA1 (0.49) | SMN1; SMN2RAB9AMAPTNPC1RECQL | |
| SCHEMBL2583163 | 0.70 | HSP90AA1 (0.49) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |