Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585338 | 0.82 | KMT2A (0.48) | KMT2ALMNAMEN1SMN1; SMN2TSHR | |
| SCHEMBL4264521 | 0.81 | TSHR (0.50) | KMT2ALMNAMEN1SMN1; SMN2TSHR | |
| SCHEMBL2585252 | 0.81 | PKM (0.46) | KMT2ALMNAMEN1SMN1; SMN2TSHR | |
| SCHEMBL2582055 | 0.80 | TSHR (0.50) | KMT2ALMNAMEN1SMN1; SMN2TSHR | |
| SCHEMBL325035 | 0.75 | ALDH1A1 (0.40) | KMT2ALMNAMEN1SMN1; SMN2TSHR | |
| SCHEMBL5243723 | 0.75 | TSHR (0.47) | KMT2ALMNAMEN1SMN1; SMN2TSHR | |
| SCHEMBL2582300 | 0.72 | ALDH1A1 (0.58) | KMT2ALMNAMEN1SMN1; SMN2TSHR | |
| SCHEMBL2582303 | 0.72 | ALDH1A1 (0.58) | KMT2ALMNAMEN1SMN1; SMN2TSHR | |
| SCHEMBL5527687 | 0.72 | PKM (0.44) | KMT2ALMNAMEN1TSHRALDH1A1 | |
| SCHEMBL2586012 | 0.69 | MEN1 (0.47) | KMT2ALMNAMEN1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |