Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2578646 | 0.83 | HSP90AA1 (0.50) | TSHRSMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL2585338 | 0.82 | KMT2A (0.48) | TSHRSMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL2579153 | 0.80 | KMT2A (0.45) | TSHRSMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL4264521 | 0.80 | TSHR (0.50) | TSHRSMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL2585252 | 0.76 | PKM (0.46) | TSHRSMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL2588237 | 0.75 | SMN1; SMN2 (0.47) | TSHRSMN1; SMN2RAB9ANPC1MAPK1 | |
| SCHEMBL5243723 | 0.71 | TSHR (0.47) | TSHRSMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL2582303 | 0.70 | ALDH1A1 (0.58) | TSHRSMN1; SMN2LMNAMAPK1KMT2A | |
| SCHEMBL2582300 | 0.70 | ALDH1A1 (0.58) | TSHRSMN1; SMN2LMNAMAPK1KMT2A | |
| SCHEMBL5527687 | 0.70 | PKM (0.44) | TSHRLMNAMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |