Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404702 | 0.81 | EPHX2 (0.41) | LMNAKDM4EALDH1A1PKMKMT2A | |
| SCHEMBL2400651 | 0.81 | EPHX2 (0.45) | LMNAALDH1A1TSHRPKMKMT2A | |
| SCHEMBL2400618 | 0.78 | SMN1; SMN2 (0.45) | LMNAKDM4EALDH1A1TSHRHPGD | |
| SCHEMBL5120411 | 0.78 | ALDH1A1 (0.51) | LMNAKDM4EALDH1A1TSHRPKM | |
| SCHEMBL2399881 | 0.77 | LMNA (0.44) | LMNAKDM4EALDH1A1TSHRPKM | |
| SCHEMBL6410614 | 0.77 | LMNA (0.46) | LMNAKDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL2404676 | 0.75 | ALDH1A1 (0.45) | LMNAALDH1A1PKMKMT2AMAPT | |
| SCHEMBL2400838 | 0.74 | HTR6 (0.43) | LMNAALDH1A1TSHRPKM | |
| SCHEMBL2400837 | 0.74 | LMNA (0.43) | LMNAKDM4EALDH1A1TSHRPKM | |
| SCHEMBL2404708 | 0.73 | LMNA (0.40) | LMNAKDM4EALDH1A1TSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048890-B2 | Analgesics; neuropathic pain; headaches; muscle relaxants; incontence; tinnitus; diarrhea; antiarrhythmia agents; antiischemic agents; antiinflammatory agents; antiulcer agents; antidepressants; antiepileptic agents | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |