Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 5/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TK1 | P04183 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579453 | 1.00 | DNMT1 (0.46) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL2575404 | 0.89 | DNMT1 (0.48) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL2575407 | 0.89 | DNMT1 (0.48) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL7598712 | 0.88 | DNMT1 (0.52) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL12582475 | 0.88 | DNMT1 (0.52) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL7598717 | 0.88 | DNMT1 (0.52) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL2583109 | 0.87 | TK1 (0.51) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL2583113 | 0.87 | TK1 (0.51) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL2579556 | 0.85 | TK1 (0.61) | DNMT1ADRB1CYP1A2CYP3A4TSHR | |
| SCHEMBL2579557 | 0.85 | TK1 (0.61) | DNMT1ADRB1CYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10100076-B2 | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation | GILEAD PHARMASSET LLC (US) | 2018-10-16 | — | — | US | disclosed |
| US-20140057863-A1 | MODIFIED NUCLEOSIDES FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | GILEAD SCIENCES, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| US-20110269707-A1 | Modified nucleosides for the treatment of viral infections and abnormal cellullar proliferation | PHARMASSET, INC. | 2011-11-03 | — | — | US | disclosed |
| EP-2251015-A1 | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation | Pharmasset, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140057863-A1 | MODIFIED NUCLEOSIDES FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | SLC29A1, PNP, SLC29A2 | DNMT1 2568/4885ADRB1 744/4885CYP1A2 506/4885 |
| US-20110269707-A1 | Modified nucleosides for the treatment of viral infections and abnormal cellullar proliferation | PNP, ALPP, XDH | DNMT1 2658/4885ADRB1 1219/4885CYP1A2 1267/4885 |
| US-10100076-B2 | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation | SLC29A1, SLC29A2, PNP | DNMT1 3151/4885ADRB1 349/4885CYP1A2 702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.