Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ATF4 | P18848 | 11/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555345 | 0.83 | ALDH1A1 (0.55) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL22669296 | 0.82 | ATF4 (0.55) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL25796695 | 0.81 | ALDH1A1 (0.59) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL22669060 | 0.81 | ATF4 (0.52) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL25802434 | 0.80 | ALDH1A1 (0.51) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL20999062 | 0.79 | ALDH1A1 (0.50) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL20999199 | 0.78 | ALDH1A1 (0.52) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL23483883 | 0.78 | ATF4 (0.45) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL25797486 | 0.78 | ALDH1A1 (0.52) | ALDH1A1ATF4GRIN1GRIN2BMEN1 | |
| SCHEMBL20999264 | 0.76 | ATF4 (0.54) | ALDH1A1ATF4GRIN1GRIN2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |