Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24133840 | 0.88 | HPGD (0.56) | HPGDKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL17817678 | 0.80 | ALDH1A1 (0.53) | HPGDKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL31707340 | 0.75 | KDM4E (0.72) | HPGDKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL23016847 | 0.73 | ALDH1A1 (0.48) | HPGDKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL17817582 | 0.72 | KDM4E (0.59) | HPGDKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL28444260 | 0.72 | HPGD (0.69) | HPGDKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL17817598 | 0.71 | KDM4E (0.58) | HPGDKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL12774630 | 0.71 | CYP2D6 (0.42) | HPGDKDM4ELMNACYP3A4HIF1A | |
| SCHEMBL28550309 | 0.70 | ALDH1A1 (0.60) | HPGDKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL5798716 | 0.69 | KDM4E (0.55) | HPGDKDM4EALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219898-A1 | COMPOUNDS AND METHODS FOR BLOCKING APOPTOSIS AND INDUCING AUTOPHAGY | HARVARD COLLEGE (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219898-A1 | COMPOUNDS AND METHODS FOR BLOCKING APOPTOSIS AND INDUCING AUTOPHAGY | BECN1, SQSTM1, ATG7 | HPGD 2304/4885KDM4E 2447/4885ALDH1A1 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.