Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 9/20 | 0.58 |
| ▸ | IL1B | P01584 | 14/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25798526 | 0.88 | IL1B (0.66) | NLRP3IL1BACHE | |
| SCHEMBL25798266 | 0.88 | IL1B (0.59) | NLRP3IL1BCHRM2CHRM4RAB9A | |
| SCHEMBL25798125 | 0.87 | IL1B (0.67) | NLRP3IL1B | |
| SCHEMBL25798371 | 0.85 | IL1B (0.62) | NLRP3IL1B | |
| SCHEMBL25798525 | 0.83 | IL1B (0.60) | NLRP3IL1B | |
| SCHEMBL25798369 | 0.82 | IL1B (0.72) | NLRP3IL1B | |
| SCHEMBL25798528 | 0.80 | IL1B (0.63) | NLRP3IL1B | |
| SCHEMBL25797812 | 0.80 | NLRP3 (0.78) | NLRP3IL1B | |
| SCHEMBL25798115 | 0.80 | IL1B (0.62) | NLRP3IL1B | |
| Hydrochloric Acid SCHEMBL2712723 | 0.79 | RAB9A (0.57) | NLRP3IL1BCHRM2CHRM4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129987-A1 | PYRIDAZINE DERIVATIVES AS MODULATORS OF NLRP3 INFLAMMASOME AND RELATED METHODS | Neumora Therapeutics, Inc. (US) | 2023-07-06 | — | — | WO | disclosed |