Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769648 | 0.83 | — | — | |
| SCHEMBL5595915 | 0.82 | ALDH1A1 (0.36) | GLO1ALDH1A1LMNAHSD17B10MAPT | |
| SCHEMBL464895 | 0.81 | — | — | |
| SCHEMBL3291190 | 0.81 | — | — | |
| SCHEMBL20302153 | 0.80 | ALDH1A1 (0.44) | NPSR1ALDH1A1MAPTHCAR2TSHR | |
| SCHEMBL2214385 | 0.77 | — | — | |
| SCHEMBL7688610 | 0.73 | — | — | |
| SCHEMBL322511 | 0.73 | GLO1 (0.50) | GLO1NPSR1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL19447665 | 0.73 | GLO1 (0.50) | GLO1NPSR1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL222772 | 0.73 | GLO1 (0.50) | GLO1NPSR1ALDH1A1CYP2D6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1710482-B1 | LAMINATED TUBE | UBE INDUSTRIES (JP) | 2013-04-17 | — | — | EP | disclosed |
| US-8067075-B2 | Multilayer tube | UBE INDUSTRIES, INC. (JP) | 2011-11-29 | — | — | US | disclosed |
| US-20070148389-A1 | Multilayer tube | Ube Industries, Ltd. a corporation of Japan, 1978-96 (JP) | 2007-06-28 | — | — | US | disclosed |
| EP-1710482-A1 | LAMINATED TUBE | Ube Industries, Ltd. (JP) | 2006-10-11 | — | — | EP | disclosed |